Active substances: Orlistat
Rimonabant, an appetite-suppressant drug, is the first selective cannabinoid-1 CB 1 receptor blocker, and CB 1 receptor plays a role in the regulation of appetitive behavior.
In, the use of rimonabant was suspended by EMA due to an increased risk of psychiatric side effects such as anxiety, suicidal ideation, sleep disorders, and depression. Subsequently, in EMA also suggested suspending the use of sibutramine.
Common side effects of sibutramine are due to activation of the sympathetic nervous system such as insomnia, dry mouth, constipation, anorexia, headache, palpitation, and hypertension.
Currently only orlistat Xenical, a drug which is considered to be acting through inhibition of pancreatic lipase enzyme, a key enzyme for the digestion of dietary triglycerides, has been approved by FDA and is available for long-term treatment of obesity.
Orlistat is the saturated derivative of lipstatin isolated from a Gram-positive bacterium Streptomyces toxytricini. Apart from its antiobesity activity, it can also modestly decrease blood pressure, prohibit the onset of diabetes type 2, and improve oral glucose tolerance.
In 1998, it was approved and is considered the only existing drug for the long-term control of obesity.
Despite the promising results of orlistat for obesity treatment, it is associated with certain unpleasant gastrointestinal side effects.
Hence, it is crucial to discover novel inhibitors, derived from natural sources particularly plants that are not associated with these serious side effects. Several strategies have been applied for development of antiobesity agents including increase of energy expenditure by blocking adipogenesis or inducing lipolysis followed by fat oxidation and reduction of energy intake by suppressing appetite and delaying or inhibiting absorption of nutrition.
Naltrexone is an opioid receptor antagonist, initially approved as a treatment for opiate addiction, and later, for alcohol dependence.Amoxicillin for cats otc Cats amoxicillin otc for - Buy Without Prescription Canada Gathering Wilhelm's mints, his Buy neurontin online enhanced modiolo submitted uncontroversially.
Studies carried out on a small number of patients using naltrexone in monotherapy as an anti-obesity agent proved frustrating, with little or no reduction in body weight. Despite these drugs having a modest efficacy when used in isolation, current understanding of the complex processes of central and peripheral appetite regulation enabled the hypothesis of a possible synergistic effect of their combination.
The increase of dopamine and norepinephrine levels mediated by bupropion stimulates the neural activity of proopiomelanocortin POMC.