Active substances: Orlistat
Check with your doctor if you have questions. If you also take cyclosporine, do not take it within 2 hours before or after Xenical.
If you miss a dose of Xenical, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. However, monotherapies have limited efficacy, in part due to the recruitment of alternate and counter-regulatory pathways.
Finally, challenges in anti-obesity drug development are discussed.
Introduction Obesity is a complex medical condition characterized by excessive, abnormal fat accumulation as a result of increased intake of energy-dense foods and decreased physical activity WHO,.
The dramatic rise in obesity is attributed to genetic susceptibility, environmental factors such as availability of energy dense foods and sedentary life style lacking adequate physical activity.
The rise in global obesity rates over the last three decades has been substantial, presenting a major public health epidemic in both developed and developing countries Ng et al. To date, there have not been any safety signals that have emerged to suggest that any of the currently available medications are not suitable for use in the long term.
Conclusion Understanding of the various weight-loss medications available, indications, common side effects and limitations in specific patient populations allows general practitioners GPs to decide if, and which, pharmacotherapy is appropriate when managing patients with obesity.
Similarly, if the medication produces satisfactory weight loss and is well tolerated, it should not be discontinued empirically. Rather, medications reinforce lifestyle management and play a useful role in long-term management of obesity.
By widening the repertoire in their toolbox, GPs can increase the probability of identifying a combination of treatment options that can help their patients manage overweight and obesity.
Case Sally, 34 years of age, had been attending your practice for many years.
She had a past medical history of obesity, hypertension, dyslipidaemia and polycystic ovary syndrome. Sally had previously tried to lose weight with lifestyle interventions, including VLEDs and structured exercise programs, and achieved modest weight loss of 5 kg, which was not sustainable.
She was keen to lose weight to improve her health and overall wellbeing, and wished to explore other options to aid with her efforts to lose weight.
Adjunctive therapies with pharmacotherapy or surgery would be appropriate considerations in this case.It was packed very professionally.
Phentermine was considered but not chosen given her hypertension. Liraglutide was commenced, with a starting dose of 0.
Sally was unable to tolerate higher doses because of gastrointestinal side effects. The medication improved her adherence to caloric restriction, and she achieved weight loss of 5 kg.
She discontinued liraglutide six months ago because of cost constraints. Xenical works to stop the absorption of fat from your food. By reducing the fat that is absorbed from your diet Xenical can help you lose weight more easily.
If you miss a dose of Xenical, take it as soon as possible. Ok, which contains increases from the Hoodia stopgap.
By drive the fat that is continued from your diet Xenical can justify you lose weight more rapidly.