Active substances: Norfloxacin
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Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect.
The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. This might increase the risk of methotrexate toxic reactions.
Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0.
The effects on the periurethral and anal canal flora were similar in both groups.