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A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus.
Current therapies to shorten postoperative ileus.
Methylnaltrexone, a new peripherally acting mu-opioid receptor antagonist being evaluated for the treatment of postoperative ileus.
Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice.
CGRP antagonists and capsaicin on celiac ganglia partly prevent postoperative gastric ileus. Calcitonin gene-related peptide and spinal afferents partly mediate postoperative colonic ileus in the rat.
Mechanisms and treatment of postoperative ileus. Inhibition of gastrointestinal transit due to surgical trauma or peritoneal irritation is reduced in capsaicin-treated rats.
Activation of an adrenergic and vagally-mediated NANC pathway in surgeryinduced fundic relaxation in the rat. Postoperative ileus: a review.
Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus.
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