Active substances: Doxycycline
It is classified as a long-acting tetracycline, although this classification scheme is somewhat artificial since tetracycline classified as short-acting can be dosed at longer intervals than usually occurs in clinical practice.
Several other mechanisms have been proposed but not studied. The second-generation tetracyclines, doxycycline, and minocycline, are preferred for the treatment of acne because of lower prevalence of resistant P.
Collagenase breaks down connective tissue which leads to the separation of the gum from the tooth.
Products e. Doxycycline concentrations produced by Periostat are too low to exert a direct antibacterial effect. Clinical studies of patients receiving Periostat for 9 to 18 months show that Periostat has no effect on total anaerobic and facultative bacteria in plaque samples.
Periostat should not be used as an antibiotic in the treatment of periodontitis. Distribution is extensive due to the relatively high lipid solubility of doxycycline compared to other tetracyclines, although only small amounts diffuse into CSF.
Only minocycline is more lipid-soluble. The major route of doxycycline excretion is via the feces with minimal amounts excreted renally e. Serum half-life ranges from 12 to 25 hours, depending on single or multiple dosage, in adults with normal renal function.
Peak serum doxycycline concentrations of 1. These reductions in AUC and Cmax can be clinically significant. However, like all other tetracyclines except minocycline, doxycycline is not hepatically metabolized. Mild hepatic impairment should have no effect on doxycycline pharmacokinetics.
Studies have shown no significant difference in serum half-life of doxycycline range: 18 to 22 hours in individuals with normal and severely impaired renal function.
Hemodialysis does not alter the serum half-life. Doxycycline is associated with photosensitivity reactions after sunlight UV exposure, with these reactions occurring somewhat less frequently than with demeclocycline.
Photosensitivity reactions are believed to be due to accumulation of the drug in the skin and are mostly phototoxic in nature, but photoallergic reactions also can occur with select drugs.
Sulfites cause an allergic reaction in some people and this product should be used with caution in patients with a known sulfite hypersensitivity.
This sensitivity reaction is more common in patients with asthma than in non-asthmatic patients. Adequate and well-controlled studies of doxycycline use in pregnant women are lacking.
The vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure.
There are no human data available to assess the effects of long-term therapy of doxycycline in pregnant women such as that proposed for treatment of anthrax exposure.